Manufacturing Presentation

Scaffold based rp technologies contd one major

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Unformatted text preview: known as solid free- form fabricaHon is a class of well- established techniques to manufacture prototypes from complex 3D datasets [10]. All rapid prototyping processes are based on the same principle of building 3D models layer by layer [10]. Compared to convenHonal methods, Rapid Prototyping (RP) Technologies offer an efficient way to control the design, fabricaHon, and modeling of the scaffold being constructed. [10] RAPID PROTOTYPING TECHNOLOGIES cont’d Due to the capability to fabricate complex 3D shapes with controlled internal structure, the use rapid prototyping to generate scaffolds is a promising area [10]. The selected material must be compaHble with the Rapid Prototyping process and it must be efficiently produced in the form required [1]. The general approaches applied in the TE include cell- seeded polymeric scaffolds, cell- seeded gels, and cell self- assembly into cellular matrices [8]. RAPID PROTOTYPING TECHNOLOGIES cont’d Among these, cell- seeded polymeric scaffold approach is the most commonly used method for arHficial Hssue regeneraHon, and many consider this technique as the classic TE approach [8]. It involves 3D porous structure (i.e., scaffold) into or onto which cells are placed [8]. Then the adhered cells organize themselves into a 3D assembly having similar characterisHcs as natural extracellular matrix arrangements and interacHons [8]. SCAFFOLD BASED RP TECHNOLOGIES ConvenHonal methods (such as gas foaming, emulsion freeze drying, melt molding and various others) used to manufacture scaffolds have been incapable of precisely controlling the pore size, scaffold geometry, and construcHon of internal channels within the scaffold. [1] Among all the available RP techniques, extrusion based techniques are the most advanced scaffold fabricaHon technique due to their ability of using different biomaterials, their possibility of manufacturing scaffolds in a cell- friendly environment, and their feasibility of controlled drop- on demand high precision deposiHon [8]. SCAFFOLD BASED RP TECHNOLOGIES cont’d One major drawback of the convenHonal methods is the fact that porous scaffolds cannot be produced with full control of the geometrical parameters, such as pore size, pore interconnecHon size and porosity [2]. For example, scaffolds fabricated by the combinaHon of photopolymerizaHon and salt leaching ofen contain...
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