Ch.12 + 8 Handout

Ch.12 + 8 Handout - Name:_ BIO201C Weeks 8-9 Material TA:...

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Name:____________________             Weeks 8-9 Material BIO201C       TA: Sarah Ventre, Email: sjventre@buffalo.edu Nucleus: 1. Defining boundary: Nuclear envelope. It is a double membrane with nuclear pores 2. Support Structures: Nuclear Lamina (IFs) and Nuclear matrix (scaffolding?) 3. DNA and associated proteins- Chromatin in the nucleoplasm 4. Transcription “machinery”- Transcription in the nucleus and translation in the  cytoplasm 5. Nucleolus- Site of rDNA transcription and ribosomal subunit assembly  Transport through the Nuclear Pore: 1. Importin joins with a protein that has a Nuclear Localization Signal (NLS protein).  2. This complex binds to nuclear pore cytoplasmic filaments.  3. The complex moves into the nuclear pore and then into the nucleus. 4. Importin is brought back into the cytoplasm for another round. Transport Through Nuclear Pores: Imported to the nucleus: A. Ribosomal Proteins B. Proteins for Transcription C. Proteins for DNA Replication D. IFs, matrix proteins, etc. Exported from the nucleus: A. Ribosomal Subunits B. mRNA C. tRNA D. Many other things Nuclear Localization Signal: NLS: part of the amino acid sequence of an NLS protein that targets the NLS protein to 
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This note was uploaded on 04/08/2008 for the course BIO 201 taught by Professor Janicke during the Spring '08 term at SUNY Buffalo.

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Ch.12 + 8 Handout - Name:_ BIO201C Weeks 8-9 Material TA:...

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