Mutations put deleterious alleles into the population

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Unformatted text preview: terious alleles into the population" " µ = mutation rate s = selection intensity q = allele frequency *Wirth et al. 1997. Am. J. Human Genetics 61: 1102-1111. Mutation-Selection Balance! •  Mutations put deleterious alleles into the population" •  Selection acts to remove deleterious mutations "" µ = mutation rate s = selection intensity q = allele frequency *Wirth et al. 1997. Am. J. Human Genetics 61: 1102-1111. Mutation-Selection Balance! •  Mutations put deleterious alleles into the population" •  Selection acts to remove deleterious mutations" •  Mutation puts them back (deleterious alleles persist) "" equilibrium frequency of deleterious allele* µ q = s * if recessive µ = mutation rate s = selection intensity q = allele frequency (q2 is genotype frequency) *Wirth et al. 1997. Am. J. Human Genetics 61: 1102-1111. Mutation-Selection Balance! •  Mutations put deleterious alleles into the population" •  Selection acts to remove deleterious mutations" •  Mutation puts them back (deleterious alleles persist) "" equilibrium frequency of...
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