human anatomy lecture notes 4

Basale keratinocytes when basal keratinocytes move up

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Unformatted text preview:  ­ desmosomes at cell ­cell interfaces and hemidesmosomes at cell ­basement membrane; hemidesmosomes attach epidermis to dermis and also maintain stem cell phenotype of s. basale keratinocytes  ­ when basal keratinocytes move up in to the next stratum they begin to differentiate  ­ contains melanocytes, which produce skin pigment and are neural ­crest derived; migrate into the epidermis and reside in the stratum basale  ­ contains Merkel cells, which may be mechano/touch receptors, and are neural ­crest derived; migrate into the epidermis and reside in the stratum basale Stratum Spinosum  ­ differentiation of the epithelial keratinocytes begins as the cells begin to produce large numbers of keratin intermediate filaments (= tonofilaments)  ­ desmosomes are very prominent at all cell ­cell interaction points at the ends of small keratinocyte cell processes ( spines of 'stratum spinosum’ ­ see figure 14.03)  ­ Langerhans cells, whic...
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This note was uploaded on 01/16/2014 for the course CAPS 390 taught by Professor Calvinroskelley+others during the Fall '13 term at The University of British Columbia.

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