human anatomy lecture notes 5

Hematopoietic niches are made up of small clusters of

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Unformatted text preview: derived  ­ In this course we will only consider the myeloid stage in any detail Hematopoietic Stem Cell (HSC) = Hematocytoblast  ­ Can self ­renew (generate more HSC)  ­ Is pluripotent/multipotent as it can give rise, ultimately, to all of the cells of the blood and megakaryocytes that produce platelets.  ­ Generates two distinct lineage progenitors 1. Myeloid lineage progenitors  Granulocytes/ Erythrocytes/ Monocytes /Megakaryocytes (=GEMM; this is the textbook definition) 2. Lymphoid Lineage progenitors  B and T lymphocytes and Natural Killer Cells Hematopoietic Cords  ­ Regions in bone marrow that contains HSC, lineage progenitors, blasts, and supportive stromal cells where blood cell production takes place  ­ Hematopoietic cords are located close to venous sinusoids (large, open capillaries), which allows cells to ente...
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