human anatomy lecture notes 5

E always turned on in chronic myelogenous leukemia cml

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Unformatted text preview: r and leave bone marrow easily.  ­ Hematopoietic niches are made up of small clusters of developing blood cells and stromal cells within the larger Hematopoietic cords. Regulation of Hematopoiesis  ­By growth factors, cytokines, colony stimulating factors produced by stromal cells in the bone marrow (ie. short range acting/paracrine factors). An example of this is 'Stem Cell Factor' (SCF)  ­By hormones produced in another organ (long range acting) An example of this is 'Erythropoietin' that acts on Erythroid lineage Stem Cell Factor Drives HSC and lineage progenitor cell proliferation  ­c ­Kit is a tyrosine ­kinase linked transmembrane receptor on the HSC and progenitor cells that binds to the paracrine/short ­range acting Stem Cell Factor (SCF).  ­This activates the intrinsic enzymatic activity of the receptor (tyrosine phosphorylation) which initiates multiple signaling pathways resulting in blast/precursor cel...
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