10-Cellular Division-STUDENTVERSION-2

13 132013 cell cycle clock 2 main regulatory

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Unformatted text preview: oint "Restriction point" • ___________-most important in mammals • If cell receives: – Green light: continues to S phase ________ – Red light: exits cell cycle, G0 enters ____ Is the cell big enough, are conditions favorable, is there any DNA damage, etc.? 13 1/3/2013 Cell Cycle Clock • 2 main regulatory molecules Cyclins – _______ • Levels fluctuate cyclically – Cyclin-dependent kinases (cdks) _____________________ • Present at constant concentrations but usually inactive • Activated by attaching to cyclins Maturation-Promoting Factor (MPF) G2 Checkpoint ____________ (G2 to M) cyclin cdk Protein dimer consisting of a ______ and ____ • Targets include: – Condensins – Proteins involved in mitotic spindle formation – Lamins • Proteins involved in nuclear envelope assembly/breakdown 14 1/3/2013 Anaphase Promoting Complex (APC) M phase __________ Checkpoint (Metaphase to Anaphase) Complex of 11-13 proteins that marks cell cycle proteins for degradation External Factors Growth Factors • ___________ - cell will grow until they hit their neighbor; then they will stop – i.e. Plateletderived growth factor (PDGF) • Density-dependents ____________ inhibition Anchorage • ____________ dependence 15...
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This note was uploaded on 01/14/2014 for the course BIO 1113 taught by Professor Rothacker during the Winter '12 term at Ohio State.

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