S04 Screening & Diagnostic Tests (FILLED IN)

False negaves or false posives 1 depends on

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Unformatted text preview: o iden.fy correctly those who do not have the disease –  The proporNon of disease free/negaNve that test negaNve Gold Standard •  Perfect test: absolutely valid! –  Every diagnosis is correct and no misdiagnoses –  “external source of truth” •  Obviously, very few exist in pracNce –  ImperfecNons of all tests –  Biological variability hUp://resourcenewsreport.com/wp- content/uploads/2012/07/pnf.gif “A normal individual is a person who has not been sufficiently examined.” - Anonymous Varia.on of Popula.ons •  Natural variaNon “anemic” “normal” –  Everyone is different –  Unimodal vs Bimodal distribuNons –  Example: •  iron anemia and hemoglobin Figure 2 Frequency distribu.on of hemoglobin values of 200 one- year- old children (Hu et al. 2010. JCIM Vol 8, Issue 7) Canadian Blood Services (blood.ca) Cutpoints •  •  •  •  •  •  •  Healthy: led...
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