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Unformatted text preview: ine Protein HH N H3C Protein Protein OH HH N O O OH Protein Threonine ATP ADP Protein O ADP Protein O HH N H3C P OH OH O Protein O O P OH OH The Human Kinome A Sequence- based classificaAon of Human protein kinases SelecAvity is an issue Enzymatic catalysis: kinases N- lobe αC helix Protein kinase A is activated by cyclic AMP (10 nM) C- lobe Protein Kinase A Cyclic AMP is an intracellular messenger mediating the physiological action of hormones through the action of protein kin...
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This note was uploaded on 01/15/2014 for the course CHEM 167 taught by Professor Amaro during the Winter '13 term at UCSD.

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