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Pseudomonas aeruginosa problem 3 range of acvity

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Unformatted text preview: ili#es Systemic bloodstream infec#ons in immuno- compromised pa#ents can be fatal - among all infec#ons with gut bacteria, the propor#on caused by carbapenem- resistant types rose to 4 percent in 2012, from 1 percent in 2001 - among infec#ons caused by one type of bacteria, Klebsiella, 10 percent have become resistant, compared with 2 percent a decade ago. Drug- resistant Klebsiella, traced to one pa#ent, caused a notorious outbreak in 2011 at an NIH hospital Seventeen other people were infected, and six of them died. Forty- two states have had cases of carbapenem- resistant infec#on. The problem is most common in the Northeast, par#cularly in hospitals in NYC. Na#onwide, about 4 percent of short- stay hospitals reported such infec#ons in the first half of 2012, but the rate was much higher — 18 percent — among long- term acute- care hospitals, which treat people who need ven#lators for a long #me or who have other chronic problems. New Delhi metallo- beta- lactamase 1 (NDM1) -   Enzyme that makes bacteria resistant to beta- lactam an#bio#cs -   Gene is one member of a large family of enzymes that encodes beta lactam enzymes -   Bacteria that harbor these genes are called SUPERBUGS because they cause infec#ons so difficult to treat -   Usually these bacteria are only suscep#ble to an#bio#cs that rupture the bacterial cell membranes Horizontal gene transfer = nightmare scenario!! Problem 3 - Range of Ac#vity Factors 1) Cell wall may have a coat preven#ng access to the cell 2) Excess transpep#dase enzyme may be present 3) Resistant transpep#dase enzyme (modified structure) 4)...
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