UF_3010_jandrew.pptx

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Unformatted text preview: ultiphase multiferroics –  Multilayer structures magnetostrictive piezoelectric magnetostrictive •  H P Interfacial coupling –  Increase interfacial area with multi-layer fibers –  The order of the phases may be important! Andrew Research Group - University of Florida Cobalt Ferrite/ Barium Titanate/ Cobalt Ferrite Andrew Research Group - University of Florida Order of the structure matters Andrew Research Group - University of Florida How many layers can we make? Andrew Research Group - University of Florida Bio-applications of Multiferroics •  Provide a minimally invasive approach to induce electric fields in vivo •  E-fields in biology –  Typically range of 0-10 V/cm –  Cell membranes up to 105 V/cm •  Medical fields H-fields between 5-10 kA/m will produce biologically relevant fields Andrew Research Group - University of Florida Cell Viability •  Lactate Dehydrogenase (LDH) Assay –  LDH is an enzyme that is released from damaged, dying, or dead cells 1.4 1.4 1.2 1.2 1 1 0.8 0.8 0.6 0.6 0.4 0.4 0.2 0.2 0 0 living cells dead cells janus BT CF living cells MG63 dead cells janus SHSY5Y Andrew Research Group - University of Florida CF BT Cell Viability •  Live/Dead Assay 1.2 1.6 1.4 1 1.2 0.8 1 0.6 0.8 0.6 0.4 0.4 0.2 0.2 0 0 living cells dead cells janus BT CF living cells dead cells MG63 janus CF BT CF BT SHSY5Y 2 1.8 1.6 1.4 1.2 1 0.8 0.6 0.4 0.2 0 1.8 1.6 1.4 1.2 1 0.8 0.6 0.4 0.2 0 living cells dead cells janus BT CF living cells MG63 dead cells janus SHSY5Y Andrew Research Group - University of Florida Cell Viability: Effect of Ion Leaching •  Cobalt and Barium ions are both known to be toxic –  Observed no leaching of cobalt –  Small amount of leaching of barium Andrew Research Group - University of Florida Surface Functionalization of Fibers •  Functionalized the fibers with a poly(ethylene glycol)- silane to enhance biocompatibility Andrew Research Group - University of Florida Cell Viability: Post Surface-Functionalization of Fibers Andrew Research Group - University of Florida Summary   Demonstrated the ability to coelectrospin bi-phasic Janus type an...
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This note was uploaded on 01/16/2014 for the course EMA 3010 taught by Professor Unknown during the Fall '08 term at University of Florida.

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