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Unformatted text preview: functioning of the anatomy. MRI has been
around for as long as PET scanning and takes
advantage of the magnetic properties of the
body. The basic difference between fMRI and
MRI is MRI is anatomical view (so only see
differences in the tissue, high res. and only
need to take one picture) whereas fMRI the
image has a lower resolution, but it is able to
pick up the deoxygenated hemoglobin has a
different property than oxygenated
hemoglobin. So it takes advantage of the
relative ratio of the these 2.. Thus the idea is
increase in metabolism = increase in ratio =
activation of that brain area. Noisy, so also
must avg. images together. … fMRI
Blood Oxygenation Level Dependent: (BOLD) signal
indirect measure of neural activity
Whole parts of the brain are active all the
time. ↑ neural activity ↑ blood oxygen ↑ fMRI signal! Functional Magnetic Resonance Imaging (fMRI)! Flickering Checkerboard
OFF (60 s) - ON (60 s) -OFF (60 s) - ON (60 s) - OFF (60 s) The ﬁrst BOLD fMRI functional
mapping of the brain!
Kwong et al., 1992!
Developed in the late 80s and 90s, and used ﬂickering
checkerboard in order to prove validity of the technique. In the
picture, can see visual lobe is activated when looking at the
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This note was uploaded on 01/18/2014 for the course PSY 123 taught by Professor Staff during the Fall '11 term at UCSB.
- Fall '11