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Unformatted text preview: Macdonald (1991)! Rare patient with both Anterograde and Retrograde amnesia. Damage to both
temporal lobe in both hemispheres, and medial temporal cortex. Tulving has
shown that KC can learn new associations over time. No episodic memories
through out his entire life, but does still retain semantic memory and working
memory. Beyond the current 2 or 3 minutes, he cannot recall beyond that. Having
as much trouble trying to imagine future as trying to recall the past. Perhaps also
important in stimulating future actions. Animal Models of Medial Temporal Lobe Dysfunction! Delayed Nonmatch-To-Sample Task:
(a) A food reward is place under the
object. (b) The door is opened and the
monkey is allowed to pick up the object
to receive the reward. (c) The door is
closed and a new object with the food
reward is placed next to the old object.
(d) The monkey must choose the new
object in order to receive the reward.!
The monkey has to be able to remember what the old object was, and
choose the other object to get the food reward. Have to be able to
think back to the previous episode and realize that they need to pick
the new one. It turns out that when they take out the MTL it greatly
affects their ability to do this task, creating an amnesia like symptom.
This procedure is much more anatomically precise than what you can
do in humans. The worst memory loss in monkeys occurs when you
have much more than the hippocampus being damaged (for example
the surrounding outer cortex of the hippocampus). # of cortical areas
that surround the hippocampus called parahippocampal regions. It
includes the perirhinal cortex and the parahippocampal cortex. And
then these areas are connected to various regions of the brain. These
2 are kind of like bottleneck of the information before it goies into the
hippocampus. The hipocampus thus acts to integrate this information
from different areas of the brain. Animal Models of Medial Temporal Lobe Dysfunction!
Selective lesions have found that the most severe memory impairments occur when the
hippocampus is damaged along with the surrounding parahippocampal regions (PHC),
including the perirhinal (PRC) and entorhinal...
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- Fall '11