Psy 123_Lec 11 Memory

Rare patient with both anterograde and retrograde

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Unformatted text preview: Macdonald (1991)! Rare patient with both Anterograde and Retrograde amnesia. Damage to both temporal lobe in both hemispheres, and medial temporal cortex. Tulving has shown that KC can learn new associations over time. No episodic memories through out his entire life, but does still retain semantic memory and working memory. Beyond the current 2 or 3 minutes, he cannot recall beyond that. Having as much trouble trying to imagine future as trying to recall the past. Perhaps also important in stimulating future actions. Animal Models of Medial Temporal Lobe Dysfunction! Delayed Nonmatch-To-Sample Task: (a) A food reward is place under the object. (b) The door is opened and the monkey is allowed to pick up the object to receive the reward. (c) The door is closed and a new object with the food reward is placed next to the old object. (d) The monkey must choose the new object in order to receive the reward.! The monkey has to be able to remember what the old object was, and choose the other object to get the food reward. Have to be able to think back to the previous episode and realize that they need to pick the new one. It turns out that when they take out the MTL it greatly affects their ability to do this task, creating an amnesia like symptom. This procedure is much more anatomically precise than what you can do in humans. The worst memory loss in monkeys occurs when you have much more than the hippocampus being damaged (for example the surrounding outer cortex of the hippocampus). # of cortical areas that surround the hippocampus called parahippocampal regions. It includes the perirhinal cortex and the parahippocampal cortex. And then these areas are connected to various regions of the brain. These 2 are kind of like bottleneck of the information before it goies into the hippocampus. The hipocampus thus acts to integrate this information from different areas of the brain. Animal Models of Medial Temporal Lobe Dysfunction! Selective lesions have found that the most severe memory impairments occur when the hippocampus is damaged along with the surrounding parahippocampal regions (PHC), including the perirhinal (PRC) and entorhinal...
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