Pavlov cephalic B 12 IF 2014

brings o2 bicarbonate production mucus production

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Unformatted text preview: fect = secretion rate & volume of stomach acid – Hormones (gastrin, histamine), feedback, neural input, paracrine effects: • Example = PGs (prostaglandins) Prostaglandins • Effects on GI tract, especially stomach: intestinal blood flow – brings in: • Nutrients • NaCl, H2O, CO2 (products = ?) • Brings O2 bicarbonate production mucus production – Facilitate epithelial cell repair/renewal • Concern = NSAIDs, aspirin One view of Dogs Dogs vs. Cats: ….. And now .. we go to the we next phase: Intestinal Phase Intestinal • TRIGGERS → what effects this time? TRIGGERS this – Volume – stretch Rc – pH – chemo-Rc – Osmolarity – osmo-Rc • Effects on ENTERO-GASTRIC REFLEX – Intestinal hormones (CCK, secretin) – Intestinal nervous system – Effects on gastric emptying Glucose Effects Glucose • Blood glucose ↑ during digestion Blood during • Results include effects on – Cephalic phase (Vagus n.) activity – Gastrin secretion (which way?) – Acid secretion (which way?) – Pancreas NZ secretion – Pancreas insulin secretion Stomach, mucus, B-12, Helicobacter Helicobacter Some general information: Some Digestive secretions • • • • • • • Water Acid Mucus - protection Bicarbonate - protection Enzymes Hormones, paracrines (ex. PGs) Other molecules (tropins, drugs, Other toxins, etc.) toxins, Acid production/alkaline tide NaHCO3 NaCl CO2 H2O zinc alkaline HCl Carbonic anhydrase ACID Stomach lumen Bloodstream Parietal cell in stomach Mucus Mucus P mucus P P P-o gen P acid -oge n Mucus includes Mucin Mucus • Single mucin molecule – Single long, unfolded polypeptide + long CHO side chains side • Neighbor mucins Neighbor intertwine = protective intertwine barrier barrier Eicosanoids – all made in mitochondria Eicosanoids Exert paracrine effects = locally made, locally active Can be Pro- or anti-inflammatory Can Prostaglandins • Effects on GI tract, especially stomach: intestinal blood flow – brings in: • Nutrients • NaCl, H2O, CO2 (products = ?) • Brings O2 bicarbonate production mucus production – Facilitate epithelial cell repair/renewal • Concern = NSAIDs, aspirin Vitamin B-12 & Intrinsic Factor Vitamin B 12 Vitamin MW = 1355 daltons (Glc = 180 Hgb = 64,000) B 12 required Energy production and storage for later use – growth, repair Critical for cell and tissue growth and repair Critical Species Differences Species Intrinsic factor • Dogs Dogs – Stomach 20% (which cells?) – Pancreas 80% • Cats – Stomach 0% – Pancreas 100% Pancreas 100% – Possible issues?...
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This note was uploaded on 01/20/2014 for the course ANISCI 5032 taught by Professor Dr.anahill during the Spring '14 term at Ohio State.

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