Journey into the Small Intestine 2014

bile acids bicarbonate added by bile duct epithelial

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Unformatted text preview: ch (-), SI (+) ) Intestinal (stomach – Stomach volume = 1 oz/lb body weight • Pancreas - beta cells = hormones GIP Bile acids Bile Bile Acids Bile • Bile – 6 – 10 ml per kg body wt per day produced (1 tsp/lb) – Components = • Water, electrolytes, cholesterol, phospholipids, bilirubin, waste (toxins, meds, etc.) • Bile Acids – Bicarbonate added by bile duct epithelial cells (enzyme, cofactor, pathway?) Bile Acids Bile • Cholesterol → cholic + chenodeoxycholic acids – conjugate glycine, taurine taurine • Amphipathic – emulsify & solubilize FA + fatemulsify soluble vitamins • Secretion into Duodenum (+) by CCK, Secretion secretin secretin • Re-uptake at ileum (what else here?) • Major route for cholesterol elimination Major cholesterol – 500 mg/day in people (3 gram/wk) Taurine synthesis Taurine Taurine issues Taurine • Cats Cats • Large-breed dogs Large-breed (ex: Newfoundlands) (ex: Taurine Issues Taurine • Cats (maybe large breed dogs) = can’t conjugate bile Cats acids without taurine acids – Consequences: • Little digestion of fats (what happens to them?) • Little digestion of fat-soluble vitamins (effects?) • Littl...
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This note was uploaded on 01/20/2014 for the course ANISCI 5032 taught by Professor Dr.anahill during the Spring '14 term at Ohio State.

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