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↔ Brunner’s ↑ & intestinal ulcers
Brunner’s • Kidney failure ↔ gastrin ↑ • Common issue = excess GASTRIN
– Effects on acid secretion?
– Gastrin – also opens pyloric sphincter –
results from stomach? Effects on pH?
• Cystic fibrosis
– Inherited disorder of sweat, mucus glands
– Thick & sticky secretions block ducts
block Pancreatic ducts
Bring to duodenum
(2)Bicarbonate Response to acid digesta
– Stimuli = ACID, fatty acids, volume ↑
– Source = Small intestine mucosal cells
– Targets = epithelial (lining) cells of
• bile duct
bile – Effects = BICARBONATE release
– Feedback = ↑ pH (-)’s secretin release
release pH gradient
– Reach optimal pH for pancreatic NZ
– Microbial control
– Toxin neutralization (some)
– Parasite control Bicarbonate production
H2O alkaline Intestinal
Pancreatic duct zinc HCl Carbonic
Optimum pH = 7.0 ACID Bloodstream
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This note was uploaded on 01/20/2014 for the course ANISCI 5032 taught by Professor Dr.anahill during the Spring '14 term at Ohio State.
- Spring '14