1.Folate+lecture+1_01.08+3+slides+pp-1

7xgfolicacidinfortifiedfoodgnaturally

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Unformatted text preview: tine)  Folate bioavailability Foodfolate:~50%absorbed variableandoftenincompletebioavailability  Folicacid:  ~100%absorbedfromsupplements ~85%fromfortifiedfoods 8 1/7/2014 Factorsthatmayaffectefficiency ofintestinalabsorption Entrapmentoffolateinfood matrix Presenceofinhibitorsto intestinalGCPII Factorsaffectingstabilityof reducedfolatesindigestive systembeforeabsorption AlterationinjejunalpH drugs alcohol Folate bioavailability Folicacidinfortifiedfood1.7Xmore bioavailablethannaturallyoccurring foodfolate Basedonassumptionthatfolicacidconsumed withfoodis~85%availableandfood folate50% ratio85/50=1.7  Dietaryfolateequivalents Dietaryfolateequivalents(DFE) termtocomparesyntheticfolicacidtofood folate tocorrectfordifferencesinbioavailability betweennaturallyoccurringfood folate andfolic acid DietaryReference Intakes(DRI)expressedinDFEs (1.7xµgfolicacidinfortifiedfood)+µgnaturally occurringfoodfolate=µgDFE   9 1/7/2014 ApplicationofDFE 100 g foodfolate(e.g.spinach)  =100 g DFE  100 g folicacid(e.g.fortifiedfood) =170 gDFE (1.7X100...
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This note was uploaded on 01/19/2014 for the course HUN 4445 taught by Professor Sitren during the Fall '08 term at University of Florida.

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