1.Folate+lecture+1_01.08+3+slides+pp-1

Backtomonoglutamate glutamylhydrolase folate storage

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: g) Transportinplasma Primarytransportform   5 ­Methyl ­THF   Mostly(>50%)boundtoalbumin  Cellstakeupmonoglutamate formandconvertitto polyglutamateformforstorageanduseinenzymes  Peripheraltissueuptake Cellstakeupfolateviareducedfolatecarrier(RFC) RFCisacell ­surfacetransmembraneproteinthat transportsfolateoptimallyatpH7.4 Cellscanalsotakeupfolateviafolatereceptors Folatereceptor1(folatereceptor ) Folatereceptor2(folatereceptor ) Processinvolvesreceptor ­mediated endocytosis 10 1/7/2014 Folate carriers RFC PCFT uni ­directional protoncouplingallows concentrative transportoffolatesat acidicpH similaraffinityfor reducedfolatesand folicacid playsprimaryrolein folateabsorption bi ­directio...
View Full Document

This note was uploaded on 01/19/2014 for the course HUN 4445 taught by Professor Sitren during the Fall '08 term at University of Florida.

Ask a homework question - tutors are online