Notrequiredforabsorption canbemethylated inliver

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Unformatted text preview: evelsofPCFT   Reductionoffolicacidinintestine Withinintestinalcell,folicacidisreduced to tetrahydrofolatein2stepprocess bothstepsrequiredihydrofolate (DHF) reductase  DHFreductase easilysaturated  Oxidizedfolicacidfoundinbloodwhenmore than200 g/dose taken  Dihydrofolate reductase Folicacid Dihydrofolate reductase (DHF) NADPH NADP H H Dihydrofolate DHF Dihydrofolate reductase (DHF) NADPH NADP H H H Tetrahydrofolate THF H 7 1/7/2014 Endogenousintestinal folate Withinintestinalcell,folatecanbemethylated to5 ­methylTHFpriortoreleaseintoportal circulation intestinalmethylation notrequiredforabsorption (canbemethylated inliver) Folatesecretedintotheintestine bile(veryhighconcentrations) pancreaticsecretions Veryefficient enterohepatic recirculation  5 ­Methyl ­THF  ­circulatingformoffolate ­ (5 ­Methyl ­THFcanalsobesynthesized intheintes...
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