exam1 - Chem-l06 Second Hourly Exam Spring 2010 Name AIISM...

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Unformatted text preview: Chem-l06 Second Hourly Exam Spring 2010 Name AIISM Ke¥ TA You will be given ample time to complete this exam. The questions vary widely with point values. . This course is graded on the curve. Please write legibly. If we can’t read your answers you will not receive credit. 5. Good luckl 9w»: 1.) 8pm. mpKavalmfiorphcnylalanhumflnwnnthclcfl. AnsweI'mefollowing quemiomwithnmmthcmhumofight plan-9.4 E H ,o ‘ : pn-zz D OH H2 c I 'u‘ "“0‘6 H I EqOH DrathcnylahnincinlhcionicfomtlntwillpmdominatenmcpoimshandC. Under Z dmw an ionic fun of phaxylalanine that does not significantly exist over theentitcpflrangeofO-M. FonnatpointA FormupoinlC *3 9 m4 9 Nug- o- cmb Nab—c 1,09 l a. 6) CH. “ ivc the pH values for the following points: B D You mix0.l molesoffonnAwithOJmolesoffomE. S‘QQ Whulslhenewpfl? 2.) 6pm The amino acids in the ionic fonns and amounts shown heIow need to be brought to the pH values shown in the “desired pH” column. List the exact amount A Amino Acid 1' Amount Given Desired pH BquivBase t 2. I A 200 ml of.6M 9.7 “/1 32 av .06 mot 0": M31 a: ll ‘ pKa=9.7 I pKa=13 L Jim” ,9 MEX-006) l H e B 0.8moi 10,5 ”1.9% W “2.an N Mums 1" ms (wait ”.91 ' DKO'23 ‘1 m uu,°-c-oocr I 2.3 d H l 1 .5 Please list the atrium of K0}! in moles required to completely neutralize: A9341: 01.1mm 9., & ”Jimln 3.) l4ptstwthedtemicaistructmeofthepcptide'l‘yr-Pro-Gluintheionicfomtthat will predominate at pH 6. The side chainotht’s R group is -CHz.CHz-000H with apKaof4. Tyr'ngmuppKa is 10. ‘1 9. fl .9 *3 9 (9 “$33?” °'°'g‘-‘°.““‘99m=z.t @ . out 0 ‘ ,‘ cu; \ ‘0 QPW4 pier-to a.) How many equivnluioe ofbose will be needed to completely neutralize thisfonn Offlw peptide? 32%. b.) How many molecules of water will need to hydrolyze die original 9? - tripeptidetoaminoncids? @ c.) Whatisthcdiargeofthispeptideat pH=l H pH=8 .1. 4.) 8m lgdicafthcchugoonthcupeptidesatpfla " ImioLys-Arg-Olu-Val-Pho-Sct-Thr-VaI-Cys ‘ + ‘ + lle-Tyr-Gln-llo—Tyr-Glu-Gly-Thr-Glu—Asn " "'1 _ 2m“ +GIy-Ala—‘l‘hr—GIy—Ah-Thr-Gly-AIaOln—Trp' 0 4- - + + + + 3 1- Arg-Glu-Lys-Val-Met-Lys-Pm—Gly—Asn-Arg "* pKa’s for R groups an: as l‘oilow: min = 8.4 Glutamic Acid = 4.1 Histidinc = 6.0 Tyrosine = 10.5 Lysine = 10.5 Aspartic Acid = 3.9 Arginine = 12.5 5.) ”ms pH calculations. Show your work. a.) Whuisibeu‘oomnuadoninmiuiionof 5“'°"3 [email protected] 20 mM KOH? [mum‘s . \XD‘HM‘ [m [m = io-H b.) Whatislhem’] fornpfl of3.8? pH= 4°an quuo-QM 3.8 '- - log [H1 0.) An acid HA is dissolved in water. The pH is 4.0. I x :0" Me) What is the concentration ofA'? _ HA : H+ +A’ --[HH'A1 n: mo... M pii: 40501] 4- -\ [H d.)WhatlsthcanmttofKOI-linmolcs edto _a70)¢6‘ ‘3 complctely nwtraliu 350 ml of 0.2 M fiannic acid? oBSOLx .7132! -. ,oqm¢\ L 4 CD I o.) 0.52m1esomA(pKa52)in1Lorwmrneedoobo ammo! or flab bmughttopli 5.7. How mud: KOH shmudbcadded? Opm~ ‘lx ab. s. .szmdi ,——-—- =.2(9m0‘ 7.. f.) What ratio of [Ad/[HA] would provide the but bufl'cring ' 9) capacityforubufiu’? 6.) spa You add 0.4 moles “@me 0.1 moles @ 3.8 in a total volume of 2.5L. a.) Whatislhepllofmemixmte? W 0.1m] H. ARI” 03mm FA P'Q Mb 0 mol MON O‘imol MP; (9 pH- pram“ pt?— 39* lug .Jfi 364143 ”(3 b.) Youaddan AflSLofwath-wthesol‘a tisthepHofthediluted ”"1“"? MOM"? -‘. $fiu pH: 3513 betauao '1 O "IHA wm nacho c.) From the original mixture, how many mold of N30}! would you need to add to completely neutralize the the formic acid in the mixture? Omar Oflmdl Nam 7.) :bomorymFm ofmefollowimwmdabuflflummmingmw aboutmyequipmcnet? Givclhemos: Wmmwet. a.) Sodiumlacme+KOH+water Lactic acid+water LaoIic acid+KOI-l+wner . Sodimlm+sodiumm+m 0.) None ofthe above 8.) 6m: Draw the ionintion states for Lysine (fully [:10me to fully unpmionated). I8 label the zwitiedom. The R group of Lysine is -A CH2 -CH1 CH;— c. (93 parts it 0 on 95’ {OS §9® Nlur- (POOH-e "Nug «c. -c-oe " NH; #09 e' NH c—c—oo (EH; cux 9% WI ah ' éu‘ gawk; s 9.) lOpts Answer the following questions about the pmtcin Carbonic Anydrasc. ( “I: this summing m What a: are common to thug structure? 8‘ 3’ 1 pl!) Mama and thaw a nont ovalen v lnurocdonfound in (his ‘ .- N‘ Howm nyaain this struume b «a Nam. some who acids that might be mean! on ml: side of this secon sanctum. k“ ML / 10.) 4pm Draw a chaotmph and describe how it deotaturee pmteins. N CI .9 . AN“ W A ”Mm Hto envtronmm Drawasmoothuuveshowingdtebehnviorofasubmtewithmcme anx httahigheraffinity 34m Tag—fun. "Lg 12.) 14pm. Usemmomthantwowudstoamweachofflmqmsfions. a.) Spidmhansonduspmtein Fbmm b.) Tortoise hide undu- this protein ‘Cdllm c.) All alpha helix contain 54 amino acids would 5 have how many nuns of the helix? 1 NY“ d.) Whatfomeisvetyimpoflaminmaintainingthe mhelical Wm? M c.) Fibroin contain: this secondary stluctmc embagts __ r.) Protimdimetmimaundmmhaw WM ‘ 8-) h) i.) 1-) It.) I-) AlaninealthScanicsmnctcbargeandexiansa lwifleém‘,mxtmi The zinc ion in cuboxypcptidaao is an example of a W Protainsuucmm that contains disulfide bonds 5‘ 0‘ “I" ——_n—7-———‘~ Nunemfactomthmdammcprotcim mg, 23 WW“ Information necessary f0: a ptotein to fold is foundinits |° smmm Amhxoacidwifllseomdarymninesidechnin h; L513 B§s,Ar3 m.) Amino acidinadipoluionfoun Zwmuron W ...
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