Homework 3

Homework 3 - Homework 3 25 points due 11/13/07 Cailin...

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Homework 3 Cailin Johnson-Smart 25 points due 11/13/07 Part 1: Using Gene Gateway and NCBI to find information on Burkitt Lymphoma (a rare cancer) and Hemophilia A (a blood disorder) go to www.DOEgenomes.org Link to "Gene Gateway" in the site directory under “Human Genome Project Information” Click on “Disorder Guide” in the orange box at the top of the page. Click on “Overviews of Genetic Disorders” Under Genes and Disease, click on “listing” Click on “Burkitt lymphoma” and answer the following questions 1. What sort of viral infection appears to play a role in the condition? The Epstein-Barr virus 2. What kind of chromosomal aberration is associated with this condition? Which chromosomes are involved? Disruption of cell growth and proliferation. And Chromosome 8 is involved. 3. What is the name of the gene involved, what is its function and how is it affected by the chromosomal aberration? (use your own words here, please) Myc gene and it’s function is controlling cell growth and proliferation. Because chromosome 8 is “broken” and is allowed to “associate” with other chromosomes, chromosome 8 changes the pattern of the gene’s expression, which means that it interferes with the original function of controlling cell growth and proliferation, and thus is a genetic disorder. Click on “Hemophilia A” under the Navigation section and answer the following questions 4. What protein is missing in hemophilia A and what role does it normally serve? Factor VIII and it normally serves as the ability to clot blood. 5. What is the name of the gene encoding this protein (in previous question) and on what chromosome is it located? How does this gene location influence the relative number of males and females affected? Factor VIII and it’s located on the X chromosome. And because it’s located on the x
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Homework 3 - Homework 3 25 points due 11/13/07 Cailin...

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