KIN 3515 biochemistry

25 plasmamembrane hormone receptor calcium entry

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Unformatted text preview: miting Enzyme Enzyme Enzyme Enzyme Product(s) Hormonal Control of Metabolism .22 Release Hormone Action Circulation Binding Chemical Signalling Modulation of Enzyme Activity 4.23 How an Adrenergic Hormone Works: An example of a "Second Messenger" Epinephrine or Norepinephrine Plasma Membrane Receptor Adenyl Cyclase ATP Cyclic AMP Protein Kinase (Inactive) 5' AMP Protein Kinase (Active) Phosphorylase b (Inactive) Phosphorylase a (Active) Synthase I (Active) Synthase d (Inactive) « Binding of hormone to the receptor results in formation of Cyclic AMP (2nd Messenger). « The activation of protein kinase 1) activates phosphorylase and 2) inactivates glycogen synthase. 4.23 .24 How Steroid Hormones Work Cytoplasm DNA Nucleus H mRNA Translocation H H H H Cytoplasmic Receptor H mRNA Protein Synthesis Hormone Response How Hormones Using Ca++­Calmodulin as a Second Messenger Work .25 Plasma Membrane Hormone Receptor Calcium Entry Calcium release from organelles Cytoplasmic Ca++ Inactive Calmodulin Active Calmodulin Inactive Enzyme Active Enzyme 4.26 The Sympathetic Nervous System & Catecholamines Brain Sympathetic Nerves Adrenergic Nerves NorEpi Adrenal Medulla Epi (80%) Cholinergic Nerves Norepi (20%) Various Effects Depending on Organ Acetyl Choline Vascular Smooth m. Vasodilation (skeletal m.) .27 Control of Hormone Secretion: Insulin The secretion of all hormones is modified by a number of factors which either increase or decrease release into the b...
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This note was uploaded on 01/20/2014 for the course KIN 3515 taught by Professor Nelson during the Fall '09 term at LSU.

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