lecture 11 - Lecture #11- DNA Replication and Gene...

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Lecture #11- DNA Replication and Gene Expression (ch 8 p. 192-193, ch 9 p. 198-213, ch 10 p. 221-225) I. Replication: DNA is copied (maintenance). A. General Mechanism (fig. 8.15) 1. The two strands of the helix come apart. 2. Each of these strands serves as a template for the synthesis of a new strand. 3. The addition of nucleotides to the new strands involves complementary base pairing with the nucleotides in the template strand. B. Key Points 1. Requires enzymes: DNA Polymerase Attaches nucleotides together as they are added in Helicase Opens up the helix Others Ligase, topoisomerase 2. Begins at Origins of Replication (Oris) & proceeds in the 5’- 3’ direction Ori = region of special sequence that allows the dwindling of helix and entry of the polymerase 5’ 3’ direction 3’-OH needed to add next nucleotide 3. Is semiconservative (fig. 8.15) Each new helix contains one old and one new strand Starts from a “primer” (provides 3’ OH) 4. Occurs in all cells that are preparing to divide (S phase of the cell cycle) S = Synthesis
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II. Utilizing the DNA: Gene Expression A. Overview (fig. 9.4) 1. Central Dogma of Molecular Genetics DNA gets transcribed to mRNA (messenger RNA) mRNA gets translated to protein 2. RNA = chain of nucleotides (AGCU)
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This note was uploaded on 04/09/2008 for the course BME 80H taught by Professor Rothwell during the Winter '07 term at University of California, Santa Cruz.

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lecture 11 - Lecture #11- DNA Replication and Gene...

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