{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

lecture 11 - Lecture#11 DNA Replication and Gene...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture #11- DNA Replication and Gene Expression (ch 8 p. 192-193, ch 9 p. 198-213, ch 10 p. 221-225) I. Replication: DNA is copied (maintenance). A. General Mechanism (fig. 8.15) 1. The two strands of the helix come apart. 2. Each of these strands serves as a template for the synthesis of a new strand. 3. The addition of nucleotides to the new strands involves complementary base pairing with the nucleotides in the template strand. B. Key Points 1. Requires enzymes: DNA Polymerase Attaches nucleotides together as they are added in Helicase Opens up the helix Others Ligase, topoisomerase 2. Begins at Origins of Replication (Oris) & proceeds in the 5’- 3’ direction Ori = region of special sequence that allows the dwindling of helix and entry of the polymerase 5’ 3’ direction 3’-OH needed to add next nucleotide 3. Is semiconservative (fig. 8.15) Each new helix contains one old and one new strand Starts from a “primer” (provides 3’ OH) 4. Occurs in all cells that are preparing to divide (S phase of the cell cycle) S = Synthesis
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
II. Utilizing the DNA: Gene Expression A. Overview (fig. 9.4) 1. Central Dogma of Molecular Genetics DNA gets transcribed to mRNA (messenger RNA) mRNA gets translated to protein 2. RNA = chain of nucleotides (AGCU)
Image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern