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This prevents tangling
But also makes DNA inaccessable to gene
reading machinery Histones
Histones are proteins that help organize and
condense DNA within the nucleus.
The interaction between histones and DNA is
mediated in part by the N-terminal tail of histone
Covalent modifications to these tails help determine
whether DNA is accessible for gene transcription
(Strahl & Allis, 2000). Influencing Factors
Acetylation – acetyl molecules bind to
histones -improevs access to genes Methylation – methyl groups bind to DNA -block access to genes
-methyl and acetyl groups act as switches
-->turn genes on or off
-->no effect on underlying genes 19 5/22/13 Epigenetic Mechanisms
Chemical markings of the DNA and the
surrounding histone proteins
regulate gene activity in the central nervous
modified by experiences , particularly those occurring within the context of caregiving Roth and Sweatt, 2011 DNA methylation
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This note was uploaded on 01/21/2014 for the course PSYCH 302 taught by Professor Whitneyweikum during the Fall '13 term at University of British Columbia.
- Fall '13