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July 17 2007 first upload of data from the cancer

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Unformatted text preview: mples (500 samples for each type of tumor) 2.  Comprehensive •  DNA changes  ­ SNPs, copy number variation and structural changes •  RNA changes – genes expression and splice isoforms •  microRNA changes •  Epigenetic changes TCGA  ­ History & Timeline •  December 13, 2005 NIH launches comprehensive effort to explore genomic alterations in human tumors. •  September 13, 2006 NIH announces plans to map genomic changes of lung, brain and ovarian cancers . •  October 16, 2006 National Institutes of Health (NIH) announces components of TCGA pilot project. •  November 20, 2006 National Human Genome Research Institute announces funding for large ­scale Genome Sequencing Centers . •  July 2, 2007 TCGA awards funds for technology development . •  July 17, 2007 First upload of data from the Cancer Genome Characterization Centers to the Data Coordinating Center. •  April 2008 Revised informed consent policies established TCGA  ­ Completed Projects •  2008 TCGA reports Uirst results of comprehensive study of glioblastoma multiforme •  2011 TCGA reports Uirst results of comprehensive study of high ­ grade serous ovarian carcinoma •  2012 TCGA reports Uirst results of comprehensive study of colon and rectal cancers Nature 2008 Brain Cancer Genome Nature 2011 Genetic Signatures  ­ Ovarian Cancer !"#$%&'()#*+,-.*,+ !"#$%$&'()'*+,'-./$/'0+123 '()*+,"!-%. !"#$#%& $/#%.%& ',!-.# '()* #!(+ #!(/ !"#$ %"#& *&+ *@2 @2 A2 B2 **2 C*2 C*2 DD DD C*2 DD E2 C*2 +2 #(#$/ *@2 @2 A2 B2 **2 C*2 *,2 >74.#(?<#.#(7) !45"(6(-.#(7) 87479:;7</'=$"$#(7) Ovarian Cancer Genome Nature 2012 Colon and Rectal Cancer Genome and Genetic Signatures Colon a...
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