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Genome genome res 2009 feb19216777 featured in new

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Unformatted text preview: testing to Hind chromosomal breaks leading to cancer Translocation t(8;14) IgH ­c ­myc fusion After the human genome project We know each cancer genome has a large number of chromosomal breaks and re ­arrangements Structural Variations in Cancer •  •  Hampton et al, A sequence ­level map of chromosomal breakpoints in the MCF ­7 breast cancer cell line yields insights into the evolution of a cancer genome. , Genome Res. 2009 Feb;19(2):167 ­77 Featured in New York Times Why do we need to solve cancer genomes? •  Cancer is a set of complex diseases •  Genomic proUile of a cancer may be unique in each person. •  A deeper, more systematic understanding of cancer genomics will provide important insights into Why do we need to solve cancer genomes? •  Discover new targets for cancer treatments •  improvements in how cancer is diagnosed early •  formulate strategies for personalized medicine, –  prevention strategies based on an individual’s genetic makeup –  treatment plans based on a patient’s unique disease. The Cancer Genome Atlas Project (TCGA) •  Mission –  The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate our understanding of the genetics of cancer using innovative genome analysis technologies. •  Goals –  To improve our ability to diagnose, treat and prevent cancer. •  Funding –  National Institute of Health –  http://cancergenome.nih.gov/ What makes TCGA Unique •  Goals is to make a list of all the changes found in the DNA of cancer cells. •  Unique Aspects 1.  TCGA researchers examine a large number of sa...
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