Dnastrandelongation problem 3 replication occurs only

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Unformatted text preview: nRNAprimertoextendon 4.  Freenucleotides(dATP,dCTP,dGTP,dTTP) Addedtothe3  ­‑OHendofthenewchainasitgrows 17 Nucleotidesarethebuildingblocks(units)ofDNA ANucleotide=sugar+phosphate+base 18 DNAsynthesis Involvespolymerizationofnucleotidebases •  Polymerization of a free nucleotide •  to the growing strand •  by formation of a phosphodiester bond •  Between the 5  ­ phosphate of the free nucleotide •  And the 3  ­OH of the growing strand. 19 DNAReplication Involvesnucleotidepolymerization DNAReplicationStrategies Therearethreepossiblemechanismsforreplication 21 Messelson ­‑StahlExperiment 22 DNAReplication isSemi ­‑Conservative 23 B.DNAstrandelongation Problem 3: Replication occurs only in the 5 to 3 direction •  DNAstrandsareanti...
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