Telomere shortening triggers a dna damage response

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Unformatted text preview: catalyticcoresofDNApolIII. 43 DNAReplication: HighAccuracy&HighSpeed •  Highspeed. –  TheE.coligenomewhichis5Megabasesisreplicatedin 40minutes! –  Thisoccursatarateof2000nucleotidespersecond. –  Thereplicationforkmustmoveattherateof1000bases persecond. –  Achievedthroughthereplisome •  complicatedenzymecomplexthatmediatesallaspects ofreplication 44 Replisome: Thecellularreplicationmachinery 45 DNAreplicationineukaryotes Problem7:EukaryoticDNAispackagedintochromatin •  ProkaryotesDNAnakedinthecytoplasm •  EukaryoteshaveDNApackagedintochromatinand thereforetheadditionaltaskof… •  Disassemblingthenucleosomesduringreplication initiation •  andreassemblingthenucleosomeafterreplication termination. 46 DNAreplicationineukaryotes Assemblyofnucleosomesfollowingreplicationtermination •  Chromatinassemblyfactor(CAF ­‑1)bindshistonesandtargetsthem tothereplicationfork. •...
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This document was uploaded on 01/18/2014.

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