Lecture-9-DNA-modification- epigenetics

11 chromatinremodelinghistones 12 histonemodications

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Unformatted text preview: titutiveheterochromatin –  Alwaysintheclosedstate –  Centromere –  Telomere 6 Regions of intermediate condensation Euchromatin (least condensed) heterochromatin 7 ChromatinRemodeling 8 ChromatinRemodeling 9 ChromatinRemodeling 10 ChromatinRemodeling&Histones Althoughchromatinismadeupofmany proteinsHISTONESweresuspectedtobethe keyproteinsinvolvedinepigeneticsilencing andchromatinremodeling. 11 ChromatinRemodeling&Histones 12 HistoneModifications •  Histonesaremodifiedpost ­‑ translationally •  GeneSilencingisassociatedwith –  Methylation ­‑histonemethyltransferase (HMT) –  De ­‑acetylation ­‑Histonede ­‑ acetytransferases(HDACs) •  Geneactivationisassociatedwith –  Acetylation ­‑histoneacetyltransferase (HAT). –  De ­‑methylation 13 HistoneCode histonemodificationiscopiedfromparentalstrand 14 Histoneacetylationandgeneexpression 15 Histoneacetylationandgeneexpression 16 Histoneacetylationandgeneexpression 17 Chromatinsilencing •  GlobalGeneregulation –  Maintainschromatinin closed statewhengeneneedstobeoff –  Maintainschromatinin open statewhengeneneedstobeon •  Positioneffectvariegation –  Spreadingo...
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This document was uploaded on 01/18/2014.

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