Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: orks RNA Editing RNA Editing Mechanisms & Enzymes 1. A­to­I (Adenine to Ionosine) – Adenosine deaminases (ADAR) 2. C­to­U (deamination of cytidine to uridine) – APOBEC enzymes 3. U­insertion/deletion – Terminal Uridinyl Transferase (TUTase) Lac Operon Lac Operon Lactose Present 40 Lac Operon Lac Operon 1. Constitutive Mutations: Operator mutations 41 Oc is dominant over O+ 42 Lac Operon Lac Operon 1. Constitutive Mutations: Inducer mutations 43 I+ is dominant over I­ 44 Lac Operon Lac Operon 2. Super­repressor mutations – Inducer mutations 45 Is is dominant over I+ 46 Catabolite Repression Catabolite Repression The Lac operon is repressed in the presence of glucose 47 Catabolite Repression: Catabolite Repression: Lac operon 48 Arabinose Operon Arabinose Operon Dual positive negative control 49 Tryptophan Operon Tryptophan Operon 3. Attenutation • The trp mRNA leader sequence contains an attenuator region. • Followed by two Trp operons. 50 Attenutation­Tryptophan Operon Attenutation­Tryptophan Operon 51 Chromatin silencing • Global Gene regulation – – Maintains chromatin in ‘...
View Full Document

This document was uploaded on 01/18/2014.

Ask a homework question - tutors are online