Homologousrecombinationgeneconversion

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Not possible to exploit complementary strand information – Non­homologous end joining (3A) • Used by terminally differentiated cells which have stopped dividing are unable to take advantage of replication based error free repair systems • – Error prone – sequences at the termini maybe lost. Homologous recombination & gene conversion • Used by cells which are able to divide • Sister chromatid exchange – (3B) • Homologous recombination and gene conversion – (3C) 17 Double stranded break repair: Double stranded break repair: 3A. Non­Homologous End­Joining •Occurs in non dividing cells •Un­repaired DS breaks may undergo chromosome rearrangements •avoid serious consequences such as cell death and precancerous state 18 Double Stranded Break repair: Double Stranded Break repair: 3B. Sister chromatid exchange 19 Double Stranded Break repair: Double Stranded Break repair: 3B. Sister chromatid exchange 20 Double Stranded Break repair: Double Stranded Break repair: 3C. Homologous Recombination & Gene Conversion 21 Double Stranded Break repair: Double Stranded Break repair: 3C. Homologous Recombination & Gene Conversion 22 A View of the Gene Structure in Eukaryotes A View of the Gene Structure in Eukaryotes • Transcription always occurs in the 5’ to 3’ direction just like replication. Transcription in Eukaryo...
View Full Document

Ask a homework question - tutors are online