5_Biol221 Lecture 5 01_27_11

Additive effects of pym and rfi mutations on trichome

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Unformatted text preview: in the same or different genes? How can we tell if these are allelic? 24 Test for Dominance F1 cross cross ComplementaAon Test F1 cross cross RFI endoreduplicaAon PYM endoreduplicaAon endoreduplicaAon RFI PYM endoreduplicaAon RFI PYM RFI PYM endoreduplicaAon Perazza, D. et al. Genetics 1999;152:461-476 Copyright © 2007 by the Genetics Society of America Figure 8. Additive effects of pym and rfi mutations on trichome nuclear DNA content endoreduplicaAon RFI PYM endoreduplicaAon RFI PYM RFI PYM endoreduplicaAon Perazza, D. et al. Genetics 1999;152:461-476 Copyright © 2007 by the Genetics Society of America Coat Color in Labrador Retrievers B_ bb Coat color is achieved by the action of at least 2 genes B_E_ ee ee bbE_ The melanocortin 1 receptor (Mc1r) is encoded by the Extension locus in many different mammals, where a loss-of-function causes exclusive production of red/yellow pheomelanin, and a constitutively activating mutation causes exclusive production of black/brown eumelanin. In the domestic dog, breeds with a wildtype E allele, e.g., the Doberman, can produce either pigment type, whereas breeds with only the ee\ allele, e.g., the Golden Retriever, produce exclusively yellow pigment. Coat color pathway E B MSH MCR1 TYRP1 eumelanin Black labs MCR1 is ON independent of MSH: E B MCR1 TYRP1 eumelanin E B MSH MCR1 TYRP1 eumelanin Yellow labs X The B genes are responsible for melanin production in the hair and the nose and lips B_ bbee B_ee bb Indicative of recessive epistasis when one crosses a BbEe dog to a BbEe dog you get a 9:4:3 ratio of black:yellow:brown coat color Indicative of recessive epistasis when one crosses a BbEe dog to a BbEe dog you get a 9:4:3 ratio of black:yellow:brown coat color Figure 8. Additive effects of pym and rfi mutations on trichome nuclear DNA content endoreduplicaAon RFI PYM endoreduplicaAon RFI PYM RFI...
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This note was uploaded on 01/20/2014 for the course BIOL 221 taught by Professor Gallagher,kimberly during the Spring '13 term at UPenn.

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