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Unformatted text preview: will be discussed at the beginning of the class Microbial Fermenta<on •  Grow cells in large vessels for genera<on of product •  Microbial fermenta<on under either aerobic or anerobic condi<ons •  Classified as type I, II, or III (based on the <me at which a specific metabolite appears rela<ve to the exponen<al growth phase) Fermenta<on suite of Genentech Ocean Side Facility (6x16K) 16000L Bxr (Cap) Incubator shaker Laboratory fermentor Industrial- scale fermentor Scale up •  Scale- up is s<ll an art, not a science •  In a bioreactor, changes in environment can lead to genera<on of new reac<on pathways, new enzymes, and new products (living cells); different to conven<onal chemical reactor Microbial cells: prokaryotes vs eukaryotes Nucleus Organelles Cytoplasm (cytosol/organelles) Plant and animals Fungi: molds (mul<cellular) yeast (unicellular) 10-100 µm Similari<es: 1.  Cell membrane consis<ng of lipids 2.  DNA that stores code for all the proteins 3.  Transfer of the DNA via RNA 4.  Protein synthesis No nucleus Most are Single- celled organisms ~25x10- 14 g/cell 1- 1.5 kg bacterial/human...
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This note was uploaded on 01/20/2014 for the course CHE 489 taught by Professor Wang during the Spring '10 term at USC.

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