Lecture1

For biotechnology process development todays class

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Unformatted text preview: t one report. You must claim your topic by Jan. 30th by sending an email to the instructor and the TA. The topic must be approved by the instructor and TA. The dran of the report will be submibed by March 27 and will be reviewed by two students. Wriben review cri=que will be due on April 3rd. You have rest of =me to finalize the report. Powerpoint presenta=ons should be provided to the instructor via email before your lecture Possible topics for the case study •  bioenergy and models of bioprocessing systems for cellulose, grain, or sugar cane ethanol produc=on, •  economic model for transi=on of world liquid fuels from oil to renewable sources, and economics of conserva=on and biofuels on reduc=on of CO2 genera=on, •  applica=ons of genomics for sequencing of microbial genomes, forensic applica=ons in bird flu or food pathogens tracking, •  bioprocess design and process for produc=on of monoclonal an=bodies and human binding factors for an=cancer therapeu=cs, or an=viral drugs - tamiflu, protease inhibitors, •  bioprocess design for produc=on of vaccines (biologics, virus like par=cles, DNA) and the role of Gates Founda=on in vaccine dissemina=on and World health, •  design and microfabrica=on of DNA or protein biochips for human and animal diagnos=cs, •  microfluidics for liquid based nanotechnology for design of micro- bioreactors . for biotechnology process development Today’s class •  What is biochemical engineering? •  Modern biotechnology •  Microbial fermenta=on –  Fermentor Read chapters 1, 2 and 4 –  Prokaryotes/Eukaryotes –  Composi=on formula –  Cell growth media –  Cell growth phases –  Cell growth expression –  Classifica=on of fermenta=on –  Stoichiometry and yield coefficient Biochemical/Bioprocess Engineers •  Conduc=ng biological processes on an industrial scale, providing the link between biology and chemical engineering (Aiba, Humphrey and Millis, 1973) •  The domain of microbial and enzyme process, natural or ar=ficial; include wasterwater treatment, industrial fermenta=on and enzyme u=liza=on (Bailey and Ollis, 1977) •  The extension of chemical engineering principles to systems using a biological catalyst to bring about desired chemical transforma=on (Shuler and Kargi, 1992) Difference between biologists and engineers •  Engineers’ strength: Mathema=cal theories and quan=ta=ve methods to microbiology, biochemistry, cell biology, gene=cs and molecular biology •  Biologists’ strength: Laboratory tools and the interpreta=on of data from complex systems. Model HIV Dynamics Biochemical/Bioprocess Engineers •  What s...
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This note was uploaded on 01/20/2014 for the course CHE 489 taught by Professor Wang during the Spring '10 term at USC.

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