C341F2011Chapter7NS

Page 20 of 24 c341fall 2011 chapter

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Unformatted text preview: easoning. i. iii. ii. iv. v. vi. Circle which of the following is a better leaving group and provide a valid argument for your reasoning. i. ii. NH iii. iv. Page 19 of 24 NH C341/Fall 2011 Chapter 7: Nucleophilic Substitution Reactions Provide substitution mechanisms and major product(s) for the following reactions. Page 20 of 24 C341/Fall 2011 Chapter 7: Nucleophilic Substitution Reactions Page 21 of 24 C341/Fall 2011 Chapter 7: Nucleophilic Substitution Reactions Page 22 of 24 C341/Fall 2011 Chapter 7: Nucleophilic Substitution Reactions Provide a viable step‐by‐step mechanism using mechanistic arrows to clearly demonstrate the following reaction outcome. Through what substitution mechanism MUST this reaction have proceeded? OCH3 Br NaOCH3 CH3OH + OCH3 How else could you have synthesized this product or obtained only one product? Page 23 of 24 C341/Fall 2011 Chapter 7: Nucleophilic Substitution Reactions Design a synthesis for the following molecule starting from (R)‐2‐ chlorobutane. O Describe best conditions for the following transformation. CN OH Page 24 of 24...
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