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Balasubramani et al burns 27 2001 manufacturing

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Unformatted text preview: ighly prolifera/ve and widely used in regenera/ve medicine •  Bovine type ­I collagen –  Collagen is essen/al for wound healing –  Established immunogenic tolerance in humans for xenogeneic scaffold2 –  Clinical cases of hypersensi/vity have rarely manifested2 [2]M. Balasubramani et. al. /Burns 27 (2001) Manufacturing General Design Constraints •  Biocompa/bility –  Apligraf© has no clinical case of elici/ng immunogenic response –  All the donor immune cells (like Langerhans cells) are lost during forma/on of epidermal layer •  Ease of fabrica/on –  Allogeneic mass produc/on of cells is a developed skillset •  Steriliza/on –  Effec/ve protocols for selec/on of donor and animal protein sources •  Cost –  Pri...
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