Balasubramani et al burns 27 2001 manufacturing

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ighly prolifera/ve and widely used in regenera/ve medicine •  Bovine type ­I collagen –  Collagen is essen/al for wound healing –  Established immunogenic tolerance in humans for xenogeneic scaffold2 –  Clinical cases of hypersensi/vity have rarely manifested2 [2]M. Balasubramani et. al. /Burns 27 (2001) Manufacturing General Design Constraints •  Biocompa/bility –  Apligraf© has no clinical case of elici/ng immunogenic response –  All the donor immune cells (like Langerhans cells) are lost during forma/on of epidermal layer •  Ease of fabrica/on –  Allogeneic mass produc/on of cells is a developed skillset •  Steriliza/on –  Effec/ve protocols for selec/on of donor and animal protein sources •  Cost –  Pri...
View Full Document

This document was uploaded on 01/22/2014.

Ask a homework question - tutors are online