This so called silent rejecon provides a potent smulus

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Unformatted text preview: ced at $28/cm2*, various cost benefit analyses3 have concluded that Apligraf© improves the quality of life of recipients * As in 2010; [3] Steinberg et. al. Specific Design Constraints •  Op/mize wound healing –  Dermal layer provides necessary proteins, cytokines and growth factors to facilitate healing processes •  Pain relief –  Burt et al (1989) noted that recipient cells replace donor cells at recipient site. –  This so called ‘silent rejec/on’ provides a potent s/mulus for healing and alleviates pain •  Biomechanical proper/es –  Compression therapy, invariantly, accompanies applica/on of Apligraf© and thus biomechanical proper/es are seldom discussed –  However, autologous skin is expected to replace the implant as a part of wound healing Clinical trials and studies •  Trial Design: –  Apligraf© vs AutograQ/Conven/onal therapy with pa/ent being its own control [4,5] –  Apligraf© with and without compression therapy [6] –  Apligraf© vs. other conven/onal therapies [4,7] –  Apligraf© for healing non ­healing wounds [8,9]...
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This document was uploaded on 01/22/2014.

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