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L07 Peptides

L07 Peptides - Lecture 7 Pep des Key Concepts The size and...

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Lecture’7’Pep+des’
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Key’Concepts’ The size and composition of polypeptides exhibit tremendous but not unlimited variety Protein sequence determines its folded structure and function Some peptides are biologically active (not as proteins)
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Levels’of’protein’structure’
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Polypep+de’Diversity’ Eukaryo+c’cells,’from’yeast’to’human,’contain’ some’6,000’to’30,000’protein-encoding’genes’ and’at’least’as’many’proteins.’ Proteins’are’synthesized’in’the’order’speciFed’by’ the’sequence’of’nucleo+des’in’a’gene’ Theore+cal’possibili+es’from’polypep+des’are’ unlimited’ ±or’a’protein’of’ n ’residues,’there’20 n ’possible’ sequences.’ Rela+vely’small’100’residues’protein,’there’are’20 100 ≈’1.27’ x’10 130 ’possibili+es’
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Actual’polypep+des’are’limited’in’size’ and’composi+on’ 100’≈’1000’residues’in’general’
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L07 Peptides - Lecture 7 Pep des Key Concepts The size and...

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