L07 Peptides


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Unformatted text preview: more difficult to fold to na+ve structure •  Mul+- subunit proteins •  Frequency of amino acid composi+on is not equal (Da) Molecular weight ≈ 110 daltons/residue hemoglobin RNA polymerase myoglobin cytochrome c hexokinase serum albumin lysozyme ribonuclease glutamine synthetase similar to <<n hVp://www.rcsb.org/pdb/sta+c.do?p=educa+on_discussion/educa+onal_resources/index.html Distribu+on of Yeast proteins by # of proteins vs. Size Distribu+on of Yeast proteins by Abundance vs. Size Warrringer & Blomburg (2006) BMC Evol Biol 6:61 Amino Acid Composi+on of Proteins •  highly variable + Leu, Ala, Glu, Ser – Trp, Cys, His, Met •  different for each protein •  Average MW of one residue = 110 The func+on of protein depends on its amino acid sequenc...
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