noniden9cal subunits phage cro protein homodimer

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Unformatted text preview: ubunit protein = a dimer, 3 subunits = trimeric protein, 4 = tetrameric, etc. •  Homo (dimer or trimer etc.): iden9cal subunits •  Hetero (dimer or trimer etc.): noniden9cal subunits Phage λ Cro protein: Homodimer Quaternary structure α2 Berg, Tymoczko & Stryer Fig. 3.48 Hemoglobin: Heterotetramer Quaternary structure α2β2 Berg, Tymoczko & Stryer Fig. 3.49 Why would a protein “want” to have a quaternary structure? •  Error frequency in transla9on in large assemblies of proteins, such as collagen fibrils, advantages of subunit construc9on over the synthesis of one huge polypep9de chain •  Ease of folding of small vs. Large polypep9de chains domains are generally 100- 200 amino acids •  Use of same subunit in different mul9- subunit complexes com...
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