L11 Quaternary

L11 Quaternary - Lecture 11 Quaternary Structure Key...

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Lecture’11:’Quaternary’Structure’
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Key’Concepts’ Some proteins have multiple polypeptide chains (subunits) Description of the arrangement is description of the quaternary structure Arrangement of polypeptides is often symmetrical Quaternary structure is important for the function of multi-subunit proteins
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Learning’Objec9ves’ Understand and be able to explain the forces/interactions that stabilize quaternary structures Understand terms such as subunit, dimer, trimer, tetramer, etc., and know what the preFxes homo- and hetero- mean as applied to protein structure Understand the basics of symmetry. Know what is meant by terms such rotation axis, 2-fold symmetry, 3-fold symmetry, etc.
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Levels’of’protein’structure’ number,’type’and’arrangement’of’two’or’more’separate’ polypep9de’chains,’or’subunits,’which’may’be’iden9cal’ or’diFerent’
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3-dimensional’rela9onship’of’the’diFerent’polypep9de’chains’
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L11 Quaternary - Lecture 11 Quaternary Structure Key...

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