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L06 Amino Acid - Lecture 6 Amino Acids Reading Chapter 3...

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Lecture’6’Amino’Acids’ Reading:’Chapter’3’
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Key’Concepts’ There are 20 common amino acids Each amino acid has different character stereochemistry hydrophobicity or polarity ionization properties: basic, acidic hydrogen bonding Condensation of 2 amino acids forms the peptide bond , the amide linkage holding amino acid residues in peptide and protein polymers
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Learning’Objec=ves’ Names, structures, single and triple letter abbreviations of 20 amino acids General chemical properties of each amino acid Approximate p K a s of functional groups Ionization properties of functional groups and what inFuences them Role of amino acids in maintaining protein structure and stability Posttranslational modi±cation of amino acids
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Amino’Acids’–’Essen=al’Build’Block’
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Biological’Func=ons’of’Amino’Acids’ Building’blocks’of’proteins’ Dictate’the’folding’and’stability’of’proteins’ Catalyze’most’of’the’reac=ons’in’living’things’ Basic’component’of’biological’recogni=on’ Some’amino’acids’and’amino’acid’deriva=ves’ func=on’as’hormones’and’regulatory’ molecules’ Energy’source’(not’main)’–’ingested’proteins,’ recycling’of’=ssue’proteins’
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Basic’structure’of’Amino’Acid’ Proteins’are’polymers’of’ α-amino’acids’ 20’amino’acids’in’ proteins’ diFer’by’nature’of’ R’group,’ side chain α-carboxyl’group’ α-amino’group’
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Amino’Acids’form’Pep=de’Bond’ Condensa=on’reac=on’ à ’amide’linkage’( pep+de bond )’ polymer’
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Amino’Acids’vs.’Amino’Acid’Residues’ Dipep=de’(2),’ Tripep=des’(3),’ Oligopep=de’ (short),’ Polypep=e’(long)’ Amino’acid’ residue ’–’amino’acid’inside’pep=de C-terminus N-terminus
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Amino’Acids:’Classifca=on’ Common’amino’acids’can’be’placed’in’fve’basic’ groups’depending’on’their’R’subs=tuents:’
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