L20 462a_hemoglobin3_lec20_2012

7 25 so tetramers of deoxy but not oxy hbs aggregate

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Unformatted text preview: 43
(side
chain
in
central
cavity
of
HbF)
 –  What
chemical
difference
does
that
make
in
central
cavity?
 2,3‐BPG doesn’t bind HbF as well as HbA. Why?
 Adult:
His143
 Fetal:
Ser143

 What’s the mechanism? γ1
subunit
 Ser143 Adult:
His143
 Fetal:
Ser143

 Ser143 γ2
subunit
 Mutant hemoglobins: Learning about proteins from experiments of nature 
 •  •  •  •  •  Mutant
hemoglobins:
unique
opportuni.es
to
explore
 structure‐func.on
rela.onships
in
a
protein
 Hundreds
of
mutant
Hb’s
described,
mostly
single
AA
...
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This note was uploaded on 01/22/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Winter '08 term at University of Arizona- Tucson.

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