L20 462a_hemoglobin3_lec20_2012

Fig 7 23 othermutanthemoglobins

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: subs.tu.ons
 ~5‐7%
of
humans
carry
variant
hemoglobins,
many
of
which
are
 “silent”
phenotypically
(no
symptoms)
 But
some
cause
serious
diseases
‐‐
structure
so
delicately
 balanced
that
some
small
changes
can
seriously
affect
func.on
 Five kinds of Hb muta:ons we’ll consider:
 1.  muta.ons
that
cause
aggrega.on
 2.  muta.ons
that
lead
to
loss
of
heme
 3.  muta.ons
that
disrupt
ter.ary
structure
of
a
subunit
 4.  muta.ons
that
stabilize
methemoglobin
 5.  muta.ons
that
alter...
View Full Document

This note was uploaded on 01/22/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Winter '08 term at University of Arizona- Tucson.

Ask a homework question - tutors are online