L20 462a_hemoglobin3_lec20_2012

Esinnormalhba learningobjecves

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Unformatted text preview: s:
 –  Muta.on
in
heme
binding
pocket
leads
to
loss
of
heme.
 –  Muta.on
disrupts
ter.ary
structure
of
a
subunit.
 –  Muta.on
stabilizes
methemoglobin (Fe3+
oxida.on
state
of
 heme
in
Hb).
 –  Muta.on
stabilizes
R
state,
or
stabilizes
T
state,
compared
 with
their
normal
stabili.es
in
normal
HbA.
 Learning Objec:ves
 Explain
why
maternal
red
blood
cells
release
O2
and
fetal
red
blood
 cells
bind
O2
in
the
placenta,
including
 a)  difference
in
quaternary
structure
(subun...
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This note was uploaded on 01/22/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Winter '08 term at University of Arizona- Tucson.

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