L20 462a_hemoglobin3_lec20_2012

L20 462a_hemoglobin3_lec20_2012

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O2

to
enable
net
 movement
of
O2
from
 mother
to
fetus?

 Structural difference between HbA and HbF
 •  Quaternary
structure
 –  HbA:

α2β2
 –  HbF:

α2γ2
 •  Humans
have
several
globin
genes.

 β
and
γ
encoded
by
different
genes

 –  Expression
of
different
genes
under
developmental
 regula.on
 –  Gene
for
γ
expressed
for
last
2/3
of
fetal
life

 •  Primary
structure
 –  Several
differences,
most
importantly
‐‐
 β His 143
(side
chain
in
central
cavity
of
HbA)
 γ Ser 1...
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This note was uploaded on 01/22/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Winter '08 term at University of Arizona- Tucson.

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