L20 462a_hemoglobin3_lec20_2012

On geneforexpressedforlast23offetallife

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Unformatted text preview: orma.on
about
 nature/loca.on
of
the
muta.on
(amino
acid
subs.tu.on).

See
 examples
in
lecture
notes
and
in
Ch.5
problem
#7
in
textbook.
 Delivery of O2 from maternal Hb to fetal Hb
 •  In
vivo,
O2
must
diffuse
across
the
placenta
from
maternal
red
cells
(in
 maternal
circula.on)
to
fetal
red
cells
(in
fetal
circula.on).
 •  Maternal
Hb
(HbA)
dissociates
O2
and
fetal
Hb
(HbF)
binds
O2.
 Structural difference between
fetal
Hb

 (HbF) and
adult
Hb

 (HbA) Berg,
Tymoczko
&
Stryer,
 Biochemistry
6th
ed.,
Fig.
7‐17
 θ What
lets
fetal
Hb
bind
O2
 more
.ghtly
than
maternal
 Hb...
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