L20 462a_hemoglobin3_lec20_2012

Onaminoacidsubstuonsee

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Unformatted text preview: it
composi.on)
and
 in
protein
primary
structure
between
HbA
and
HbF;
 b)  effect
of
protein
structural
difference
on
2,3‐BPG
binding
 affinity;
 c)  resultant
difference
in
O2
binding
proper.es
between
HbA
 and
HbF
under
physiological
condi.ons,
i.e.
at
the
2,3‐BPG
 concentra.on
in
erythrocytes
in
the
placenta.
 Describe
the
molecular
defect
in
sickle
cell
anemia
and
how/why
 deoxyHbS
molecules
aggregate.
 Predict
the
effect
of
a
hemoglobin
muta.on
on
the
O2
binding
 proper.es
of
the
mutant
protein,
given
inf...
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This note was uploaded on 01/22/2014 for the course BIOC 462A taught by Professor Ziegler,baldwin during the Winter '08 term at University of Arizona- Tucson.

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