Lecture 4 slides

Hyplearngeneccsutaheducontenttechcloningcloningrisks

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Unformatted text preview: erm be appropriate to use? Who provides the host cell? 2 8/29/12 Utah geneCcs hYp://learn.geneCcs.utah.edu/content/tech/cloning/ Success rates: 1 ­10% WHY? hYp://learn.geneCcs.utah.edu/content/tech/cloning/cloningrisks/ Telomerase problems: As cells divide, their chromosomes get shorter. This is because the DNA sequences at both ends of a chromosome, called telomeres, shrink in length every Cme the DNA is copied. The older the animal is, the shorter its telomeres will be, because the cells have divided many, many Cmes. This is a natural part of aging. So, what happens to the clone if its transferred nucleus is already preYy old? Will the shortened telomeres affect its development or lifespan? When scienCsts looked at the telomere lengths of cloned animals, they found no clear answers. Chromosomes from cloned caYle or mice had longer telomeres than normal. These cells showed other si...
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