B 5 pts which enzyme is likely to have highest

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Unformatted text preview: nase activity of rubisco and production of 2 ­phosphoglycolate. Question 6. (20 pts) The following experimental values were observed for several steps in gluconeogenesis from lactate as substrate to glucose as product in liver: Substrate Lactate Oxaloacetate Glucose 6 ­phosphate Concentration 50 µM 400 µM 10 µM Enzyme Lactate dehydrogenase Phosphoenolpyruvate carboxykinase (PEPCK) Glucose 6 ­ phosphatase Km 50 µM 20 µM 100 µM (A) (5 pts) Under the conditions listed in the above table, which enzyme is likely to have highest flux control coefficient? Provide a brief explanation. Answer. PEPCK. Substrate concentration far exceeds Km, changes in substrate concentration will not likely to have an impact on reaction rate. (B) (5 pts) Which enzyme is likely to have highest elasticity coefficient? Provide a brief explanation. Answer. Glucose 6 ­phosphatase. Substrate concentration far lower than Km, changes in s...
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